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Clinical data | |
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Trade names | Lamisil, Terbin, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a699061 |
License data |
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Routes of administration | By mouth, topical |
ATC code | |
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Pharmacokinetic data | |
Bioavailability | Readily absorbed: 70–90% |
Protein binding | >99% |
Metabolism | Liver |
Elimination half-life | Highly variable |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.119.605 |
Chemical and physical data | |
Formula | C21H25N |
Molar mass | 291.438 g·mol−1 |
3D model (JSmol) | |
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Terbinafine is an antifungal medication used to treat pityriasis versicolor, fungal nail infections, and ringworm including jock itch and athlete's foot.[1][2][3] It is either taken by mouth or applied to the skin as a cream or ointment.[1][4] The cream and ointment should not be used for fungal nail infections.[5]
Common side effects when taken by mouth include nausea, diarrhea, headache, cough, rash, and elevated liver enzymes.[1] Severe side effects include liver problems and allergic reactions.[1] Liver injury is, however, unusual.[6] Oral use during pregnancy is not typically recommended.[1] The cream and ointment may result in itchiness but are generally well tolerated.[2] Terbinafine is in the allylamines family of medications.[1] It works by decreasing the ability of fungi to synthesize ergosterol.[1] It appears to result in fungal cell death.[7]
Terbinafine was discovered in 1991.[8] It is on the World Health Organization's List of Essential Medicines.[4] In 2021, it was the 245th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[9][10]
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