Tetrahydrocannabinolic acid synthase

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Tetrahydrocannibinolic acid synthase
Tetrahydrocannibinolic acid synthase
	3VTE
Identifiers
EC no.	1.21.3.7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
PMC
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Tetrahydrocannabinolic acid (THCA) synthase (full name Δ¹-tetrahydrocannabinolic acid synthase) is an enzyme responsible for catalyzing the formation of THCA from cannabigerolic acid (CBGA). THCA is the direct precursor of tetrahydrocannabinol (THC), the principal psychoactive component of cannabis, which is produced from various strains of Cannabis sativa. Therefore, THCA synthase is considered to be a key enzyme controlling cannabis psychoactivity.^[1] Polymorphisms of THCA synthase result in varying levels of THC in Cannabis plants, resulting in "drug-type" and "fiber-type" C. sativa varieties.^[2]^[3]

^ Shoyama Y, Tamada T, Kurihara K, Takeuchi A, Taura F, Arai S, Blaber M, Shoyama Y, Morimoto S, Kuroki R (October 2012). "Structure and function of ∆1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa". Journal of Molecular Biology. 423 (1): 96–105. doi:10.1016/j.jmb.2012.06.030. PMID 22766313.
^ Staginnus C, Zörntlein S, de Meijer E (July 2014). "A PCR marker linked to a THCA synthase polymorphism is a reliable tool to discriminate potentially THC-rich plants of Cannabis sativa L". Journal of Forensic Sciences. 59 (4): 919–26. doi:10.1111/1556-4029.12448. PMID 24579739. S2CID 29683549.
^ Kojoma M, Seki H, Yoshida S, Muranaka T (June 2006). "DNA polymorphisms in the tetrahydrocannabinolic acid (THCA) synthase gene in "drug-type" and "fiber-type" Cannabis sativa L". Forensic Science International. 159 (2–3): 132–40. doi:10.1016/j.forsciint.2005.07.005. PMID 16143478. S2CID 38866142.

[Shoyama_2012-1] Shoyama Y, Tamada T, Kurihara K, Takeuchi A, Taura F, Arai S, Blaber M, Shoyama Y, Morimoto S, Kuroki R (October 2012). "Structure and function of ∆1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa". Journal of Molecular Biology. 423 (1): 96–105. doi:10.1016/j.jmb.2012.06.030. PMID 22766313.

[2] Staginnus C, Zörntlein S, de Meijer E (July 2014). "A PCR marker linked to a THCA synthase polymorphism is a reliable tool to discriminate potentially THC-rich plants of Cannabis sativa L". Journal of Forensic Sciences. 59 (4): 919–26. doi:10.1111/1556-4029.12448. PMID 24579739. S2CID 29683549.

[3] Kojoma M, Seki H, Yoshida S, Muranaka T (June 2006). "DNA polymorphisms in the tetrahydrocannabinolic acid (THCA) synthase gene in "drug-type" and "fiber-type" Cannabis sativa L". Forensic Science International. 159 (2–3): 132–40. doi:10.1016/j.forsciint.2005.07.005. PMID 16143478. S2CID 38866142.

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