Transferrin receptor 1

TFRC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CX8, 1DE4, 1SUV, 2NSU, 3KAS, 3S9L, 3S9M, 3S9N
Identifiers
Aliases	TFRC, CD71, T9, TFR, TFR1, TR, TRFR, p90, IMD46, transferrin receptor
External IDs	OMIM: 190010; MGI: 98822; HomoloGene: 2429; GeneCards: TFRC; OMA:TFRC - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q29 Start 196,027,183 bp[1] End 196,082,096 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 B3|16 23.06 cM Start 32,427,738 bp[2] End 32,451,612 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell trabecular bone tibia germinal epithelium visceral pleura hair follicle parietal pleura periodontal fiber mucosa of sigmoid colon bone marrow Top expressed in fetal liver hematopoietic progenitor cell body of femur habenula stroma of bone marrow tibiofemoral joint temporal muscle human fetus vastus lateralis muscle digastric muscle ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity virus receptor activity transferrin receptor activity identical protein binding double-stranded RNA binding RNA binding protein binding Cellular component extracellular vesicle integral component of membrane recycling endosome HFE-transferrin receptor complex endosome blood microparticle membrane melanosome plasma membrane integral component of plasma membrane extracellular region cell surface basolateral plasma membrane perinuclear region of cytoplasm clathrin-coated pit extracellular exosome external side of plasma membrane extracellular space clathrin-coated vesicle membrane cytoplasmic vesicle endosome membrane early endosome Biological process endocytosis osteoclast differentiation positive regulation of bone resorption receptor-mediated endocytosis regulation of cell population proliferation regulation of cell growth viral entry into host cell viral process cellular iron ion homeostasis positive regulation of isotype switching receptor internalization transferrin transport positive regulation of B cell proliferation positive regulation of T cell proliferation membrane organization cellular response to leukemia inhibitory factor iron ion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7037 22042 Ensembl ENSG00000072274 ENSMUSG00000022797 UniProt P02786 Q62351 RefSeq (mRNA) NM_001313965 NM_001313966 NM_001128148 NM_003234 NM_011638 NM_001357298 RefSeq (protein) NP_001121620 NP_001300894 NP_001300895 NP_003225 NP_035768 NP_001344227 Location (UCSC) Chr 3: 196.03 – 196.08 Mb Chr 16: 32.43 – 32.45 Mb PubMed search [3] [4]
Wikidata
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Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene.^[5][6] TfR1 is required for iron import from transferrin into cells by endocytosis.^[7][8]