Transthyretin

TTR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BM7, 1BMZ, 1BZ8, 1BZD, 1BZE, 1DVQ, 1DVS, 1DVT, 1DVU, 1DVX, 1DVY, 1DVZ, 1E3F, 1E4H, 1E5A, 1ETA, 1ETB, 1F41, 1F86, 1FH2, 1FHN, 1G1O, 1GKO, 1ICT, 1III, 1IIK, 1IJN, 1QAB, 1QWH, 1RLB, 1SOK, 1SOQ, 1THA, 1THC, 1TLM, 1TSH, 1TT6, 1TTA, 1TTB, 1TTC, 1TTR, 1TYR, 1TZ8, 1U21, 1X7S, 1X7T, 1Y1D, 1Z7J, 1ZCR, 1ZD6, 2B14, 2B15, 2B16, 2B77, 2B9A, 2F7I, 2F8I, 2FBR, 2FLM, 2G3X, 2G3Z, 2G4E, 2G4G, 2G5U, 2G9K, 2GAB, 2H4E, 2M5N, 2NOY, 2PAB, 2QEL, 2QGB, 2QGC, 2QGD, 2QGE, 2ROX, 2ROY, 2TRH, 2TRY, 2WQA, 3A4D, 3A4E, 3A4F, 3B56, 3BSZ, 3BT0, 3CBR, 3CFM, 3CFN, 3CFQ, 3CFT, 3CN0, 3CN1, 3CN2, 3CN3, 3CN4, 3CXF, 3D7P, 3DGD, 3DID, 3DJR, 3DJS, 3DJT, 3DJZ, 3DK0, 3DK2, 3DO4, 3ESN, 3ESO, 3ESP, 3FC8, 3FCB, 3GLZ, 3GPS, 3GRB, 3GRG, 3GS0, 3GS4, 3GS7, 3HJ0, 3I9A, 3I9I, 3IPB, 3IPE, 3KGS, 3KGT, 3KGU, 3M1O, 3NEO, 3NES, 3NEX, 3NG5, 3OZK, 3OZL, 3SSG, 3TCT, 3TFB, 3U2I, 3U2J, 3W3B, 4ABQ, 4ABU, 4ABV, 4ABW, 4AC2, 4AC4, 4ACT, 4ANK, 4DER, 4DES, 4DET, 4DEU, 4DEW, 4FI6, 4FI7, 4FI8, 4HIQ, 4HIS, 4IIZ, 4IK6, 4IK7, 4IKI, 4IKJ, 4IKK, 4IKL, 5TTR, 3D2T, 3I9P, 3IMR, 3IMS, 3IMT, 3IMU, 3IMV, 3IMW, 3NEE, 3P3R, 3P3S, 3P3T, 3P3U, 4HJS, 4HJT, 4HJU, 4I85, 4I87, 4I89, 4KY2, 4L1S, 4L1T, 4MAS, 4MRB, 4MRC, 4N85, 4N86, 4N87, 4PM1, 4PME, 4PMF, 4PVL, 4PVM, 4PVN, 4PWE, 4PWF, 4PWG, 4PWH, 4PWI, 4PWJ, 4PWK, 4QRF, 4QXV, 4QYA, 4TQ8, 4TQH, 4TQI, 4TQP, 4WNJ, 4WNS, 4WO0, 4YDM, 4YDN, 5BOJ, 4Y9B, 4Y9C, 4Y9E, 4Y9F, 4Y9G, 4TKW, 4TL4, 4TL5, 4TLK, 4TLS, 4TLT, 4TM9, 4TNE, 5AKS, 5AKT, 5AKV, 5AL0, 5AL8, 5CR1, 4TNF, 4TLU, 5AYT, 4TNG, 5EZP, 4D7B, 5A6I, 5E23, 5CNH, 5E4O, 5CN3, 5EN3, 5DWP, 5K1J, 5E4A, 5HJG, 5IHH
Identifiers
Aliases	TTR, CTS, CTS1, HEL111, HsT2651, PALB, TBPA, transthyretin, ATTN
External IDs	OMIM: 176300; MGI: 98865; HomoloGene: 317; GeneCards: TTR; OMA:TTR - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q12.1 Start 31,557,009 bp[1] End 31,598,833 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 A2|18 11.47 cM Start 20,798,337 bp[2] End 20,807,378 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Epithelium of choroid plexus beta cell right lobe of liver retinal pigment epithelium body of pancreas gallbladder corpus callosum gonad C1 segment Hypothalamus Top expressed in Epithelium of choroid plexus habenula left lobe of liver ciliary body retinal pigment epithelium choroid plexus of fourth ventricle human fetus vestibular membrane of cochlear duct sexually immature organism vestibular sensory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function identical protein binding hormone binding protein binding hormone activity protein heterodimerization activity thyroid hormone binding Cellular component cytoplasm extracellular region extracellular exosome extracellular space azurophil granule lumen protein-containing complex Biological process retinol metabolic process extracellular matrix organization retinoid metabolic process purine nucleobase metabolic process neutrophil degranulation thyroid hormone transport transport regulation of signaling receptor activity signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7276 22139 Ensembl ENSG00000118271 ENSMUSG00000061808 UniProt P02766 P07309 RefSeq (mRNA) NM_000371 NM_013697 RefSeq (protein) NP_000362 NP_038725 Location (UCSC) Chr 18: 31.56 – 31.6 Mb Chr 18: 20.8 – 20.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transthyretin (TTR or TBPA) is a transport protein in the plasma and cerebrospinal fluid that transports the thyroid hormone thyroxine (T₄) and retinol to the liver. This is how transthyretin gained its name: transports thyroxine and retinol. The liver secretes TTR into the blood, and the choroid plexus secretes TTR into the cerebrospinal fluid.

TTR was originally called prealbumin^[5] (or thyroxine-binding prealbumin) because it migrated faster than albumin on electrophoresis gels. Prealbumin was felt to be a misleading name, it is not a synthetic precursor of albumin. The alternative name TTR was proposed by DeWitt Goodman in 1981.

Human transthyretrin protein is encoded by the TTR gene, which is located on the long arm of chromosome 18, in cytogenetic band 18q12.1.