US 421 highlighted in red | ||||
Route information | ||||
Maintained by INDOT | ||||
Length | 255.065 mi[1] (410.487 km) | |||
Existed | 1951–present | |||
Major junctions | ||||
South end | ![]() | |||
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North end | ![]() | |||
Location | ||||
Country | United States | |||
State | Indiana | |||
Counties | Jefferson, Ripley, Decatur, Rush, Shelby, Marion, Hamilton, Boone, Clinton, Carroll, White, Pulaski, Starke, LaPorte | |||
Highway system | ||||
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U.S. Route 421 (US 421) enters Indiana from Kentucky, proceeding northwest to Indianapolis, joining Interstate 465, and then continuing northwest to Michigan City.
US 421 winds through the southern part of Indiana as it runs from Madison, in the southeastern part of the state, to Indianapolis (the capital). North of Greensburg, US 421 intersects and merges with I-74 west, through the Shelbyville area en route to Indianapolis. Originally, US 421 followed Michigan Road into Indianapolis, which turns into Southeastern Avenue and heads to downtown. US 421 then merged with US 40 (Washington St.) and headed to West Street, then turned north, following West Street, Northwestern Avenue (later Martin Luther King Jr. Street), and Michigan Road up to the northwest side of the city. US 421 passed an Indianapolis landmark, the Pyramids. North of Indianapolis, US 421 continues to the north-northwest, providing a direct highway link between Indianapolis and Michigan City. US 421 ends at its junction with US 20 on the south side of Michigan City. Originally, the highway's end was a few miles north at the junction with US 12 near the shores of Lake Michigan.
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