U.S. Route 78

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U.S. Route 78
US 78 highlighted in red
Route information
Length	843.3 mi[citation needed] (1,357.2 km)
Existed	1926[citation needed]–present
Major junctions
West end	Future I-57 / US 67 / AR 226 near Cash, AR
Major intersections	I-55 at Blytheville, AR I-40 at West Memphis, AR I-69 at Memphis, TN I-22 at Byhalia, MS I-65 near Birmingham, AL I-20 four times in Alabama I-59 at Birmingham, AL I-75 / I-85 at Atlanta, GA I-95 at St. George, SC I-26 at North Charleston, SC
East end	Line Street at Charleston, SC
Location
Country	United States
States	Arkansas, Tennessee, Mississippi, Alabama, Georgia, South Carolina
Highway system
United States Numbered Highway System List Special Divided
Arkansas Highway System Interstate US State Business Spurs Suffixed Scenic Heritage
Tennessee State Routes Interstate US State
Mississippi State Highway System Interstate US State
← US 77 US → US 79 ← AR 77 AR → AR 78 ← SR 77 TN → SR 78 ← MS 76 MS → US 80 ← SR 3 SR 4 → SR 5 ← SR 277 SR 278 → SR 279

U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.3 miles (1,357.2 km) from Cash, Arkansas to Charleston, South Carolina. From Byhalia, Mississippi to Birmingham, Alabama, US 78 runs concurrently with Interstate 22 (I-22). The highway’s western terminus is at US 67 (Future I-57)/Arkansas Highway 226 (AR 226) near Cash and its eastern terminus is on Line Street, in Charleston. Prior to November 2023, before the western extension, the highway's former western terminus was at US 64/US 70/US 79 (Second Street) in Memphis, Tennessee.