UGT2B7

UGT2B7
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2O6L
Identifiers
Aliases	UGT2B7, UDPGT 2B9, UDPGT2B7, UDPGTH2, UGT2B9, UDP glucuronosyltransferase family 2 member B7, UDPGT 2B7, UDPGTh-2
External IDs	OMIM: 600068; MGI: 3576103; HomoloGene: 128251; GeneCards: UGT2B7; OMA:UGT2B7 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	69,112,987 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	87,240,414 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; duodenum; ; metanephric glomerulus; ; right uterine tube; ; endometrium; ; human kidney; ; testicle; ; gallbladder; ; body of pancreas;
	Top expressed in
	left lobe of liver; ; morula; ; duodenum; ; jejunum; ; ileum; ; epithelium of small intestine; ; Paneth cell; ; migratory enteric neural crest cell; ; embryo; ; human fetus;
	More reference expression data
	n/a
Gene ontology
Molecular function	glycosyltransferase activity; transferase activity; glucuronosyltransferase activity; retinoic acid binding; hexosyltransferase activity; UDP-glycosyltransferase activity;
Cellular component	integral component of membrane; organelle membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum;
Biological process	steroid metabolic process; metabolism; cellular glucuronidation; androgen metabolic process; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
	7364
	231396
	ENSG00000171234
	ENSMUSG00000070704
	P16662
	n/a
	NM_001074; NM_001330719; NM_001349568
	NM_001029867
	NP_001065; NP_001317648; NP_001336497
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

UGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain. In humans, UDP-Glucuronosyltransferase-2B7 is encoded by the UGT2B7 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171234 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070704 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ritter JK, Sheen YY, Owens IS (May 1990). "Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates". The Journal of Biological Chemistry. 265 (14): 7900–6. doi:10.1016/S0021-9258(19)39016-7. PMID 2159463.
^ Monaghan G, Clarke DJ, Povey S, See CG, Boxer M, Burchell B (September 1994). "Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13". Genomics. 23 (2): 496–9. doi:10.1006/geno.1994.1531. PMID 7835904.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171234 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070704 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2159463-5] Ritter JK, Sheen YY, Owens IS (May 1990). "Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates". The Journal of Biological Chemistry. 265 (14): 7900–6. doi:10.1016/S0021-9258(19)39016-7. PMID 2159463.

[pmid7835904-6] Monaghan G, Clarke DJ, Povey S, See CG, Boxer M, Burchell B (September 1994). "Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13". Genomics. 23 (2): 496–9. doi:10.1006/geno.1994.1531. PMID 7835904.

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