User:Identigene/paternity index

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Paternity Index In parentage testing[1], paternity index (PI) is a calculated value generated for a single genetic marker or locus[2](chromosomal location or site of DNA[3] sequence of interest) and is associated with the statistical strength or weight of that locus in favor of or against parentage given the phenotypes of the tested participants and the inheritance scenario. The term “phenotype” typically refers to physical characteristics such as body plan, color, behavior, etc. in organisms[4]. However, the term “phenotype” used in the area of DNA paternity testing refers to what is observed directly in the laboratory[5]. Laboratories involved in parentage testing and other fields of human identity employ genetic testing panels that contain a battery of loci (plural for locus) each of which is selected due to extensive allelic[6] variations within and between populations. These genetic variations are not assumed to bestow physical and/or behavioral attributes to the person carrying the allelic arrangement(s) and therefore are not subject to selective pressure and follow Hardy Weinberg inheritance patterns. The product of the individual PIs is the CPI (Combined Paternity Index)[9] which is ultimately used to calculate a the Probability of Paternity[10] seen on paternity test reports. Minimum Probability of Paternity value requirements for state cases differ between states but the AABB[11] requires in their Standards for Relationship Testing Laboratories (currently in the 9th edition)[12] a minimum of 99.0% be reported where the tested man is ‘not excluded’ as the biological father of the child in question. U.S. Department of State requires a minimum Probability of Paternity of 99.5% for all immigration cases[13]. PI calculations utilize allele frequencies[14] generated from established population databases[15] (most commonly using STR: Short Tandem Repeats[15, 16]). The following derivation sections explore calculation methods and fundamental applications of STR allele frequencies (involving loci in commonly used multiplex[16] human identity kits) for the purposes of elucidating human identity and genetic relationships. These methods are well established, widely published and utilized by relationship and forensic testing laboratories for the purposes of paternity, human identity (such as forensic application), kinship reconstruction, siblingship, grandparentage, etc. testing worldwide[17-33]. Because allele frequencies can be either generated in-house or published, PI’s can differ between companies. This is an understood phenomenon and justifiable amongst members of the testing community.