Venomics

Venomics is the large-scale study of proteins associated with venom. Venom is a toxic substance secreted by animals, which is typically injected either offensively or defensively into prey or aggressors, respectively.

Venom is produced in a specialised gland (or glands) and is delivered through hollow fangs or a stinger. The main function of venom is to disrupt the physiological processes of the wounded animal through either neurotoxic or haemotoxic mechanisms. This can then help in certain processes such as procuring prey or deterring/escaping predators. Venom has evolved many times in multiple phyla, each having developed their own unique types of venom and methods of delivery independently.[1] However, due to the excessive amounts of venomous animals in the world, they are the major cause of animal-related deaths (~ 57,000 in 2013) than non-venomous animals (~22,000).[2] For example, snakes are responsible for more than 1-5 million biting-injuries, 421,000 (to 1.8 million) envenomings and 20,000 (to 94,000) deaths annually.[3] However, with venomic methods, venom can be co-opted into beneficial substances such as new medicines and effective insecticides.[4][5]

  1. ^ Oldrati, Vera; Arrell, Miriam; Violette, Aude; Perret, Frédéric; Sprüngli, Xavier; Wolfender, Jean-Luc; Stöcklin, Reto (2016-11-15). "Advances in venomics". Molecular BioSystems. 12 (12): 3530–3543. doi:10.1039/C6MB00516K. ISSN 1742-2051. PMID 27787525.
  2. ^ Abubakar, I. I.; Tillmann, T.; Banerjee, A. (2015-01-10). "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013". Lancet. 385 (9963): 117–171. doi:10.1016/S0140-6736(14)61682-2. hdl:11655/15525. PMC 4340604. PMID 25530442.
  3. ^ Kasturiratne, Anuradhani; Wickremasinghe, A. Rajitha; de Silva, Nilanthi; Gunawardena, N. Kithsiri; Pathmeswaran, Arunasalam; Premaratna, Ranjan; Savioli, Lorenzo; Lalloo, David G; de Silva, H. Janaka (2008-11-04). "The Global Burden of Snakebite: A Literature Analysis and Modelling Based on Regional Estimates of Envenoming and Deaths". PLOS Medicine. 5 (11): e218. doi:10.1371/journal.pmed.0050218. ISSN 1549-1676. PMC 2577696. PMID 18986210.
  4. ^ Pennington, Michael W.; Czerwinski, Andrzej; Norton, Raymond S. (June 2018). "Peptide therapeutics from venom: Current status and potential". Bioorganic & Medicinal Chemistry. 26 (10): 2738–2758. doi:10.1016/j.bmc.2017.09.029. ISSN 0968-0896. PMID 28988749.
  5. ^ Windley, Monique J.; Herzig, Volker; Dziemborowicz, Sławomir A.; Hardy, Margaret C.; King, Glenn F.; Nicholson, Graham M. (2012-03-22). "Spider-Venom Peptides as Bioinsecticides". Toxins. 4 (3): 191–227. doi:10.3390/toxins4030191. ISSN 2072-6651. PMC 3381931. PMID 22741062.

© MMXXIII Rich X Search. We shall prevail. All rights reserved. Rich X Search