Vesicular monoamine transporter 2

SLC18A2
Identifiers
Aliases	SLC18A2, SVAT, SVMT, VAT2, VMAT2, solute carrier family 18 member A2, Vesicular monoamine transporter 2, PKDYS2
External IDs	OMIM: 193001; MGI: 106677; HomoloGene: 2298; GeneCards: SLC18A2; OMA:SLC18A2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	117,279,430 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	59,284,444 bp
RNA expression pattern
	Top expressed in
	pars reticulata; ; Pars compacta; ; secondary oocyte; ; tibia; ; testicle; ; skin of hip; ; islet of Langerhans; ; endometrium; ; gallbladder; ; ectocervix;
	Top expressed in
	ventral tegmental area; ; substantia nigra; ; central gray substance of midbrain; ; dorsal tegmental nucleus; ; mammillary body; ; dorsomedial hypothalamic nucleus; ; cumulus cell; ; secondary oocyte; ; zygote; ; lateral geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	monoamine transmembrane transporter activity; serotonin:sodium symporter activity;
Cellular component	integral component of membrane; clathrin-sculpted monoamine transport vesicle membrane; membrane; plasma membrane; integral component of plasma membrane; cytoplasmic vesicle membrane; cytoplasmic vesicle; synaptic vesicle; dopaminergic synapse; synaptic vesicle membrane; terminal bouton;
Biological process	locomotory behavior; response to amphetamine; post-embryonic development; serotonin transport; negative regulation of reactive oxygen species biosynthetic process; dopamine transport; neurotransmitter loading into synaptic vesicle; neurotransmitter transport; response to toxic substance; neurotransmitter secretion; sequestering of neurotransmitter; chemical synaptic transmission; monoamine transport; transmembrane transport; aminergic neurotransmitter loading into synaptic vesicle; serotonin uptake;
	Sources:Amigo / QuickGO
Orthologs
	6571
	214084
	ENSG00000165646
	ENSMUSG00000025094
	Q05940
	Q8BRU6
	NM_003054
	NM_172523
	NP_003045
	NP_766111
	Wikidata
View/Edit Human	View/Edit Mouse

Distribution of VMAT2 in the human brain.

The solute carrier family 18 member 2 (SLC18A2) also known as vesicular monoamine transporter 2 (VMAT2) is a protein that in humans is encoded by the SLC18A2 gene.^[5] SLC18A2 is an integral membrane protein that transports monoamines—particularly neurotransmitters such as dopamine, norepinephrine, serotonin, and histamine—from cellular cytosol into synaptic vesicles.^[6] In nigrostriatal pathway and mesolimbic pathway dopamine-releasing neurons, SLC18A2 function is also necessary for the vesicular release of the neurotransmitter GABA.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165646 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025094 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Surratt CK, Persico AM, Yang XD, Edgar SR, Bird GS, Hawkins AL, Griffin CA, Li X, Jabs EW, Uhl GR (March 1993). "A human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies TaqI RFLPs". FEBS Lett. 318 (3): 325–30. doi:10.1016/0014-5793(93)80539-7. PMID 8095030. S2CID 8062412.
^ Eiden LE, Schäfer MK, Weihe E, Schütz B (February 2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflügers Arch. 447 (5): 636–40. doi:10.1007/s00424-003-1100-5. PMID 12827358. S2CID 20764857.
^ Tritsch NX, Ding JB, Sabatini BL (2012). "Dopaminergic neurons inhibit striatal output through non-canonical release of GABA". Nature. 490 (7419): 262–6. Bibcode:2012Natur.490..262T. doi:10.1038/nature11466. PMC 3944587. PMID 23034651.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165646 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025094 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8095030-5] Surratt CK, Persico AM, Yang XD, Edgar SR, Bird GS, Hawkins AL, Griffin CA, Li X, Jabs EW, Uhl GR (March 1993). "A human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies TaqI RFLPs". FEBS Lett. 318 (3): 325–30. doi:10.1016/0014-5793(93)80539-7. PMID 8095030. S2CID 8062412.

[pmid12827358-6] Eiden LE, Schäfer MK, Weihe E, Schütz B (February 2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflügers Arch. 447 (5): 636–40. doi:10.1007/s00424-003-1100-5. PMID 12827358. S2CID 20764857.

[pmid23034651-7] Tritsch NX, Ding JB, Sabatini BL (2012). "Dopaminergic neurons inhibit striatal output through non-canonical release of GABA". Nature. 490 (7419): 262–6. Bibcode:2012Natur.490..262T. doi:10.1038/nature11466. PMC 3944587. PMID 23034651.

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