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Pronunciation | /vɪˈlæzədoʊn/ vi-LAZ-ə-dohn |
Trade names | Viibryd |
Other names | EMD-68843; SB-659746A |
AHFS/Drugs.com | Monograph |
MedlinePlus | a611020 |
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Routes of administration | By mouth |
Drug class | Serotonin modulator[1] |
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Bioavailability | 72% (oral, with food)[5] |
Metabolism | Liver via CYP3A4[5] |
Elimination half-life | 25 hours[5] |
Excretion | Faecal and renal[5] |
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Chemical and physical data | |
Formula | C26H27N5O2 |
Molar mass | 441.535 g·mol−1 |
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Vilazodone, sold under the brand name Viibryd among others, is a medication used to treat major depressive disorder.[1] It is classified as a serotonin modulator[1] and is taken by mouth.[1]
Common side effects include nausea, diarrhea, and trouble sleeping.[1] Serious side effects may include increased suicidal thoughts or actions in those under the age of 25, serotonin syndrome, bleeding, mania, pancreatitis, and SIADH.[1] Vilazodone may cause less emotional blunting than typical SSRIs and SNRIs.[6] A withdrawal syndrome may occur if the dose is rapidly decreased.[1] Use during pregnancy and breastfeeding is not generally recommended.[7] It is in the serotonin modulator class of medications and is believed to work both as an SSRI and activator of the 5-HT1A receptor.[1]
Vilazodone was approved for medical use in the United States in 2011[1] and in Canada in 2018.[8] In 2019, it was the 334th most commonly prescribed medication in the United States, with more than 900 thousand prescriptions.[9] The drug lost patent protection in June 2022 for adults and in July 2023 for pediatrics.[10] Generic versions have been approved by the U.S. Food and Drug Administration (FDA).[11][12]
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