William Cocke (1748–1828) was an American pioneer, state legislator, and U.S. senator.
William Cocke may also refer to:
W. A. Cocke (1796–1844), mayor of Louisville, Kentucky
William Michael Cocke (1815–1896), member of the U.S. House of Representatives from Tennessee
William A. Cocke (1822–1887), Florida Attorney General, 1873–1876
William Cocke (1672–1720) (1672 - 1720) was a prominent Virginia politician in the 1710s and as Alexander Spotswood's personal physician, was one of the first university-trained doctors in Virginia.
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