William Hamilton, 2nd Duke of Hamilton

His Grace The Duke of Hamilton KG
after Adriaen Hanneman, 1625–1650
Predecessor	James Hamilton, 1st Duke of Hamilton
Successor	Anne Hamilton, 3rd Duchess of Hamilton
Other titles	Earl of Lanark, Earl of Cambridge, Lord Machanshyre, Lord Polmont
Born	14 December 1616 Hamilton, South Lanarkshire
Died	12 September 1651(1651-09-12) (aged 34) The Commandery, Worcester
Buried	Worcester Cathedral
Noble family	Hamilton
Spouse(s)	Lady Elizabeth Maxwell
Issue	James Hamilton, Lord Polmont Anne Carnegie, Countess of Southesk Lady Elizabeth Cunningham Mary Ogilvy, Countess of Findlater Lady Margaret Blair Lady Diana Hamilton
Father	James Hamilton, 2nd Marquess of Hamilton
Mother	Lady Ann Cunningham

William Hamilton, 2nd Duke of Hamilton KG (14 December 1616 – 12 September 1651) was a Scottish nobleman who supported both Royalist and Presbyterian causes during the Wars of the Three Kingdoms.