Angiotensina

Angiotensinógeno (inhibidor de la peptidasa tipo serpina, clado A, miembro 8)
Estructuras disponibles
PDB	Buscar ortólogos:
Identificadores
Símbolos	AGT (HGNC: 333) ANHU; SERPINA8
Identificadores externos	MGI: 87963 EBI: AGT GeneCards: Gen AGT UniProt: AGT
Ontología génica Función molecular • serine-type endopeptidase inhibitor activity • hormone activity • protein binding • growth factor activity • type 1 angiotensin receptor binding • type 2 angiotensin receptor binding Componente celular • extracellular region • extracellular space • extracellular vesicular exosome • blood microparticle Proceso biológico • ovarian follicle rupture • regulation of cell growth • blood vessel development • branching involved in ureteric bud morphogenesis • positive regulation of cytokine production • kidney development • blood vessel remodeling • angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • angiotensin maturation • regulation of blood volume by renin-angiotensin • renin-angiotensin regulation of aldosterone production • regulation of renal output by angiotensin • regulation of blood vessel size by renin-angiotensin • renal system process • angiotensin-mediated drinking behavior • positive regulation of extracellular matrix constituent secretion • cellular sodium ion homeostasis • cell-matrix adhesión • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger • phospholipase C-activating G-protein coupled receptor signaling pathway • activation of phospholipase C activity • activation of NF-kappaB-inducing kinase activity • nitric oxide mediated signal transduction • cell-cell signaling • aging • excretion • establishment of blood-nerve barrier • negative regulation of cell proliferation • response to cold • response to salt stress • positive regulation of activation of JAK2 kinase activity • positive regulation of endothelial cell migration • positive regulation of cardiac muscle hypertrophy • positive regulation of macrophage derived foam cell differentiation • positive regulation of cholesterol esterification • negative regulation of endopeptidase activity • regulation of norepinephrine secretion • positive regulation of phosphatidylinositol 3-kinase signaling • artery smooth muscle contraction • response to muscle activity involved in regulation of muscle adaptation • negative regulation of angiogenesis • regulation of vasoconstriction • regulation of proteolysis • extracellular matrix organization • negative regulation of cell growth • peristalsis • positive regulation of cellular protein metabolic process • positive regulation of superoxide anion generation • positive regulation of NAD(P)H oxidase activity • negative regulation of tissue remodeling • low-density lipoprotein particle remodeling • catenin import into nucleus • regulation of renal sodium excretion • positive regulation of renal sodium excretion • positive regulation of multicellular organism growth • regulation of cell proliferation • vasodilation • positive regulation of MAPK cascade • negative regulation of neuron apoptotic process • cellular lipid metabolic process • cellular protein metabolic process • small molecule metabolic process • positive regulation of fatty acid biosynthetic process • positive regulation of epidermal growth factor receptor signaling pathway • positive regulation of transcription, DNA-templated • positive regulation of organ growth • astrocyte activation • fibroblast proliferation • positive regulation of fibroblast proliferation • regulation of long-term neuronal synaptic plasticity • smooth muscle cell proliferation • cytokine secretion • positive regulation of inflammatory response • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of NF-kappaB transcription factor activity • smooth muscle cell differentiation • negative regulation of neurotrophin TRK receptor signaling pathway • stress-activated MAPK cascade • regulation of calcium ion transport • cell growth involved in cardiac muscle cell development • positive regulation of protein tyrosine kinase activity • ERK1 and ERK2 cascade • uterine smooth muscle contraction • cellular response to mechanical stimulus • positive regulation of branching involved in ureteric bud morphogenesis • positive regulation of reactive oxygen species metabolic process • positive regulation of extrinsic apoptotic signaling pathway Referencias: AmiGO / QuickGO
Patrón de expresión de ARNm
Más información
Ortólogos
Especies	Humano Ratón
Entrez	183 11606
Ensembl	Véase HS Véase MM
UniProt	P01019 n/a
RefSeq (ARNm)	NM_000029 NM_007428
RefSeq (proteína) NCBI	NP_000020 NP_031454
Ubicación (UCSC)	Cr. 1: 230.84 – 230.85 Mb Cr. 8: 124.56 – 124.57 Mb
PubMed (Búsqueda)	[1] [2]
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Las angiotensinas son un conjunto de hormonas peptídicas derivadas del angiotensinógeno, que causan vasoconstricción y un posterior aumento de la presión arterial. Son parte del sistema renina angiotensina aldosterona (RAS), que es un objetivo importante de los fármacos que disminuyen la presión arterial. Las angiotensinas también estimulan la liberación de aldosterona, otra hormona, de la corteza adrenal. La aldosterona promueve la retención de sodio en la nefrona distal, en el riñón, que también aumenta la presión sanguínea.^[1]​

Las angiotensinas son oligopéptidos que actúan como hormonas y dipsógenos. Se derivan de la molécula precursora angiotensinógeno, una globulina sérica producida en el hígado. Juegan un papel importante en el sistema renina angiotensina aldosterona. La primera angiotensina fue aislada de forma independiente en Indianápolis y Argentina a finales de los 1930s (como 'angiotonina' e 'hipertensina', respectivamente) y posteriormente caracterizada y sintetizada por grupos en los laboratorios de la Clínica Cleveland y Ciba en Basilea, Suiza.^[2]​

1. ↑ Lu, Hong; Cassis, Lisa A; Vander Kooi, Craig W; Daugherty, Alan (julio de 2016). «Structure and functions of angiotensinogen» [Estructura y funciones del angiotensinógeno]. Hypertens Res (en inglés) 39 (7): 492-500. PMID 26888118. doi:10.1038/hr.2016.17. Consultado el 11 de abril de 2017. 
2. ↑ Basso, N.; Terragno, N. A. (diciembre de 2001). «History about the discovery of the renin-angiotensin system» [Historia acerca del sistema reina-angiotensina]. Hypertension 38 (6): 1246-1249. PMID 11751697. doi:10.1161/hy1201.101214.