Cdk5

Quinasa dependiente de ciclina 5
	; Imagen del PDB basada en 1H4L.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1H4L , 1LFR , 1UNG , 1UNH , 1UNL , 3O0G , 4AU8 Estructuras enzimáticas RCSB PDB, PDBe, PDBsum
Identificadores
Símbolos	Cdk5 (HGNC: 1774) ; LIS7; PSSALRE
Identificadores; externos	OMIM: 123831 ; MGI: 101765 ; HomoloGene: 3623 ; ChEMBL: 4036; EBI: Cdk5; GeneCards: Gen Cdk5; UniProt: Cdk5; Bases de datos de enzimas IntEnz: entrada en IntEnz; BRENDA: entrada en BRENDA; ExPASy: NiceZime view; KEGG: entrada en KEEG; PRIAM: perfil PRIAM; ExplorEnz: entrada en ExplorEnz; MetaCyc: vía metabólica
Número EC	2.7.11.1
Locus	Cr. 7 q36
Función molecular	• p53 binding; • protein kinase activity; • protein serine/threonine kinase activity; • cyclin-dependent protein serine/threonine kinase activity; • ErbB-2 class receptor binding; • protein binding; • ATP binding; • cytoskeletal protein binding; • kinase activity; • protein kinase binding; • acetylcholine receptor activator activity; • ErbB-3 class receptor binding; • ephrin receptor binding; • tau-protein kinase activity;
Componente celular	• nucleus; • cytoplasm; • cytosol; • cytoskeleton; • postsynaptic density; • membrane; • cyclin-dependent protein kinase 5 holoenzyme complex; • lamellipodium; • cell junction; • filopodium; • axon; • dendrite; • growth cone; • neuromuscular junction; • neuronal cell body; • perikaryon; • postsynaptic membrane;
Proceso biológico	• neuron migration; • synaptic transmission, dopaminergic; • intracellular protein transport; • nucleocytoplasmic transport; • cell cycle; • cell-matrix adhesión; • synaptic transmission; • axon guidance; • synapse assembly; • skeletal muscle tissue development; • blood coagulation; • motor neuron axon guidance; • cell proliferation; • visual learning; • Schwann cell development; • synaptic vesicle exocytosis; • phosphorylation; • peptidyl-serine phosphorylation; • peptidyl-threonine phosphorylation; • sensory perception of pain; • cerebellar cortex formation; • hippocampus development; • layer formation in cerebral cortex; • central nervous system neuron development; • corpus callosum development; • neuron differentiation; • regulation of cell migration; • negative regulation of axon extension; • cortical actin cytoskeleton organization; • neuron projection development; • negative regulation of protein ubiquitination; • negative regulation of synaptic plasticity; • positive regulation of protein binding; • receptor catabolic process; • serine phosphorylation of STAT3 protein; • synaptic transmission, glutamatergic; • protein localization to synapse; • regulation of apoptotic process; • receptor clustering; • positive regulation of neuron apoptotic process; • regulated secretory pathway; • negative regulation of cell cycle; • positive regulation of protein kinase activity; • negative regulation of proteolysis; • negative regulation of transcription, DNA-templated; • positive regulation of calcium ion-dependent exocytosis; • protein autophosphorylation; • negative regulation of protein export from nucleus; • behavioral response to cocaine; • regulation of synaptic plasticity; • synaptic vesicle endocytosis; • rhythmic process; • axon extension; • oligodendrocyte differentiation; • dendrite morphogenesis; • cell division; • neuron apoptotic process; • excitatory postsynaptic potential; • regulation of dendritic spine morphogenesis; • calcium ion import; • regulation of cell cycle arrest; • positive regulation of protein targeting to membrane; • negative regulation of neuron death; • regulation of synaptic vesicle recycling; • positive regulation of actin cytoskeleton reorganization; • positive regulation of receptor activity;
	Referencias: AmiGO / QuickGO
Patrón de expresión de ARNm
	Más información
Ortólogos
Humano	Ratón
1020	12568
Véase HS	Véase MM
Q00535	P49615
NM_001164410	NM_007668
NP_001157882	NP_031694
Cr. 7:; 151.05 – 151.06 Mb	Cr. 5:; 24.42 – 24.42 Mb
[1] ;	[2]
	v; t; e;
	[editar datos en Wikidata]

La quinasa dependiente de ciclina 5 es una enzima que en los humanos está codificado por el gen CDK5 .^[1]^[2] La proteína codificada por este gen es parte de la familia de quinasa dependiente de ciclina.

↑ Demetrick DJ, Zhang H, Beach DH (febrero de 1994). «Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes». Cytogenet Cell Genet 66 (1): 72-4. PMID 8275715. doi:10.1159/000133669.
↑ Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH (agosto de 1992). «A family of human cdc2-related protein kinases». EMBO J 11 (8): 2909-17. PMC 556772. PMID 1639063.

[pmid8275715-1] Demetrick DJ, Zhang H, Beach DH (febrero de 1994). «Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes». Cytogenet Cell Genet 66 (1): 72-4. PMID 8275715. doi:10.1159/000133669.

[pmid1639063-2] Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH (agosto de 1992). «A family of human cdc2-related protein kinases». EMBO J 11 (8): 2909-17. PMC 556772. PMID 1639063.

[1]

[2]