CYP2C8

CYP2C8
Proteinak kodetzen dituen genea
Identifikadoreak
Homologene: 117948 Genenames: CYP2C8 Ensemble: ENSG00000138115
Taxoia	Homo sapiens
Asoziazio-genetikoa	Baztanga osteonecrosis (en)
Kokapena
Kromosoma	human chromosome 10 (en)
Kokapen zitogenetikoa	10q23.33
Hasiera	95036772 bp[1]
Amaiera	95069497 bp[2]
Transkripzioak
RNA ID	NM_000770, NM_001198853, NM_001198854, NM_001198855 eta NM_030878
Ensembl	Zerrenda ENST00000628935 ENST00000371270 ENST00000479946 ENST00000490994 ENST00000525991 ENST00000526814 ENST00000527420 ENST00000527953 ENST00000531714 ENST00000533320 ENST00000535898 ENST00000623108
Beste espezieetan
Sagu arrunt	Cyp2c39 (en)
Sagu arrunt	Cyp2c29 (en)
Arratoi arrunt	Cyp2c7 (en)
Sagu arrunt	Cyp2c38 (en)
Gene-adierazpen eredua
Ontologia
Kodetzen du	cytochrome P450 family 2 subfamily C member 8 (en)
Funtzio-molekularrak	Ikusi oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (en) caffeine oxidase activity (en) aromatase activity (en) oxidoreductase activity (en) heme binding (en) metal ion binding (en) iron ion binding (en) arachidonic acid epoxygenase activity (en) monooxygenase activity (en) estrogen 16-alpha-hydroxylase activity (en) steroid hydroxylase activity (en) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (en) heme binding (en) monooxygenase activity (en)
Osagai-zelularra	Ikusi Erretikulu endoplasmatiko organelle membrane (en) mintza intracellular membrane-bounded organelle (en) endoplasmic reticulum membrane (en) zitoplasma intracellular membrane-bounded organelle (en)
Prozesu-biologikoak	Ikusi omega-hydroxylase P450 pathway (en) organic acid metabolic process (en) epoxygenase P450 pathway (en) oxidative demethylation (en) xenobiotic metabolic process (en) lipid hydroxylation (en) steroid metabolic process (en) long-chain fatty acid biosynthetic process (en) organic acid metabolic process (en) xenobiotic metabolic process (en) estrogen metabolic process (en)

P450 2C8 zitokromoa (CYP2C8) P450 zitokromoaren proteina-multzoko entzima da. Entzima horrek zerikusia du, besteak beste, paclitaxel, repaglinida, rosiglitazona eta zeribastatina botiken metabolismoan. Lehen, "P450 zitokromoa, IIC subfamilia (mefenitoina 4-hidroxilasa), 8 polipeptidoa" deitzen zitzaion.^[3]

1. ↑ GRCh38: Ensembl release 89: ENSG00000138115. Ensembl.
2. ↑ GRCh38: Ensembl release 89: ENSG00000138115. Ensembl.
3. ↑ genenames.org. CYP2C8. .