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Ciwon Daji na Pancreatic

Ciwon Daji na Pancreatic
Description (en) Fassara
Iri endocrine gland cancer (en) Fassara, pancreas disease (en) Fassara, pancreatic neoplasm (en) Fassara, gastrointestinal system cancer (en) Fassara
cuta
Specialty (en) Fassara oncology
gastroenterology (en) Fassara
Symptoms and signs (en) Fassara Ciwon ciki, Shawara, acute pancreatitis (en) Fassara, anorexia (en) Fassara
Trousseau's syndrome (en) Fassara
Physical examination (en) Fassara medical ultrasonography (en) Fassara, computed tomography (en) Fassara, blood test (en) Fassara, biopsy (en) Fassara
positron emission tomography (en) Fassara
Genetic association (en) Fassara SBF2 (en) Fassara, GRID1 (en) Fassara, GTF2H1 (en) Fassara, DAPK1 (en) Fassara, BACH1 (en) Fassara, DAB2 (en) Fassara, TAFA5 (en) Fassara, IL17F (en) Fassara, PRB2 (en) Fassara, DPP6 (en) Fassara, MYO1D (en) Fassara, PRKN (en) Fassara, RNF149 (en) Fassara, RNF43 (en) Fassara, BICD1 (en) Fassara, NR5A2 (en) Fassara, CLPTM1L (en) Fassara da ABO (en) Fassara
Medical treatment (en) Fassara
Magani octreotide (en) Fassara, docetaxel (en) Fassara, tamoxifen (en) Fassara, irinotecan (en) Fassara, ifosfamide (en) Fassara, fluorouracil (en) Fassara, α-streptozocin (en) Fassara, doxorubicin hydrochloride (en) Fassara, sunitinib (en) Fassara, sucrosofate (en) Fassara da erlotinib (en) Fassara
Identifier (en) Fassara
ICD-10-CM C25.0, C25.1 da C25.2
ICD-9-CM 157.1, 157.8, 157.0 da 157.2
OMIM 260350
DiseasesDB 9510
MedlinePlus 000236
eMedicine 000236
Disease Ontology ID DOID:1793

Ciwon daji na pancreatic Ya kasan ce yana tasowa lokacin da (cell)wato ƙwayoyin jini a cikin pancreas, sashin glandular bayan ciki, ya fara ninkawa daga sarrafawa kuma ya zama taro . Wadannan kwayoyin cutar daji suna da ikon mamaye wasu sassan jiki. [1] An san adadin nau'ikan ciwon daji na pancreatic. [2]

Mafi na kowa, adenocarcinoma pancreatic, lissafin kusan 90% na lokuta, [3] da kalmar "ciwon daji na pancreatic" wani lokaci ana amfani da shi kawai ga irin wannan. [2] Wadannan adenocarcinomas suna farawa ne a cikin sashin pancreas wanda ke yin enzymes masu narkewa . [2] Wasu nau'o'in ciwon daji da dama, waɗanda ke wakiltar yawancin marasa adenocarcinomas, suna iya tasowa daga waɗannan kwayoyin halitta. [2] Kimanin kashi 1-2% na lokuta na ciwon daji na pancreatic ne neuroendocrine ciwace-ciwacen daji, wanda ya taso daga kwayoyin samar da hormone na pancreas. [2] Waɗannan gabaɗaya ba su da ƙarfi fiye da adenocarcinoma na pancreatic. [2]

Alamu da ciwon daji na pancreatic da aka fi sani na iya haɗawa da launin rawaya fata, ciwon ciki ko baya, asarar nauyi da ba a bayyana ba, stools mai launin haske, fitsari mai duhu, da asarar ci . [4] Yawancin lokaci, ba a ganin alamun cutar a farkon matakan cutar, kuma alamun da ke da takamaiman isa don nuna ciwon daji na pancreatic yawanci ba sa tasowa har sai cutar ta kai mataki na gaba. [5][4] A lokacin ganewar asali, ciwon daji na pancreatic ya yadu zuwa wasu sassan jiki.[6][2]

Ciwon daji na pancreatic da wuya yana faruwa kafin shekaru 40, kuma fiye da rabin lokuta na adenocarcinoma na pancreatic yana faruwa a cikin waɗanda suka wuce 70. [5] Abubuwan haɗari don ciwon daji na pancreatic sun haɗa da shan taba, kiba, ciwon sukari, da wasu yanayi na kwayoyin halitta. [5] Kimanin kashi 25% na lokuta suna da alaƙa da shan taba, [7] da 5-10% suna da alaƙa da kwayoyin gado . [7] Ciwon daji na pancreatic yawanci ana gano shi ta hanyar haɗin fasahar hoto na likitanci kamar duban dan tayi ko ƙididdiga na hoto, gwajin jini, da gwajin samfuran nama ( biopsy ). [7][8] An rarraba cutar zuwa matakai, daga farkon (mataki I) zuwa marigayi (mataki IV).[6] Ba a sami nasarar tantance yawan jama'a ba. [9]

Haɗarin kamuwa da ciwon daji na pancreatic yana da ƙasa a tsakanin masu shan taba, da mutanen da ke kula da lafiyayyen nauyi kuma suna iyakance cin su na ja ko nama da aka sarrafa . [10] Damar masu shan taba na kamuwa da cutar suna raguwa idan sun daina shan taba kuma kusan komawa zuwa na sauran jama'a bayan shekaru 20. shekaru. [2] Ana iya magance ciwon daji na pancreatic tare da tiyata, radiotherapy, chemotherapy, palliative care, ko haɗuwa da waɗannan. [4] Zaɓuɓɓukan magani sun dogara ne akan matakin ciwon daji. [4] Tiyata ita ce kawai magani wanda zai iya warkar da adenocarcinoma na pancreatic, [6] kuma ana iya yin shi don inganta yanayin rayuwa ba tare da yuwuwar warkewa ba.[4][6] Gudanar da ciwo da magunguna don inganta narkewa ana buƙatar wasu lokuta. [6] Ana ba da shawarar kula da jin daɗi da wuri har ma ga waɗanda ke karɓar magani da ke nufin magani.[11]

A cikin 2015, ciwon daji na pancreatic kowane iri ya haifar da mutuwar 411,600 a duniya. [12] Ciwon daji na pancreatic shine sanadin mutuwa na biyar-mafi yawan gama gari daga cutar kansa a Burtaniya, [13] kuma na uku mafi yawan jama'a a Amurka. [14] Cutar ta fi faruwa a kasashen da suka ci gaba, inda kusan kashi 70% na sabbin cututtukan da aka samu a shekarar 2012 suka samo asali. [2] Pancreatic adenocarcinoma yawanci yana da mummunan tsinkaya; Bayan ganewar asali, 25% na mutane suna rayuwa shekara guda kuma 5% suna rayuwa har tsawon shekaru biyar. [2] [15] Ga cututtukan daji da aka gano da wuri, adadin rayuwa na shekaru biyar ya tashi zuwa kusan 20%. [16] Ciwon daji na Neuroendocrine yana da sakamako mafi kyau; na biyar shekaru daga ganewar asali, 65% na wadanda aka gano suna rayuwa, ko da yake rayuwa ta bambanta da yawa dangane da nau'in ciwon daji. [3]

  1. ↑ "What is Cancer? Defining Cancer". National Cancer Institute, National Institutes of Health. 7 March 2014. Archived from the original on 25 June 2014. Retrieved 5 December 2014.
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 World Cancer Report. World Health Organization. 2014. Chapter 5.7. ISBN 978-92-832-0429-9.
  3. ↑ 3.0 3.1 Unless otherwise specified in boxes, reference is: Pishvaian MJ, Brody JR (March 2017). "Therapeutic Implications of Molecular Subtyping for Pancreatic Cancer". Oncology. 31 (3): 159–66, 168. PMID 28299752.
  4. ↑ 4.0 4.1 4.2 4.3 4.4 "Pancreatic Cancer Treatment (PDQ®) Patient Version". National Cancer Institute. National Institutes of Health. 17 April 2014. Archived from the original on 5 July 2014. Retrieved 8 June 2014.
  5. ↑ 5.0 5.1 5.2 Ryan DP, Hong TS, Bardeesy N (September 2014). "Pancreatic adenocarcinoma". The New England Journal of Medicine. 371 (11): 1039–49. doi:10.1056/NEJMra1404198. PMID 25207767.
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Bond-Smith G, Banga N, Hammond TM, Imber CJ (May 2012). "Pancreatic adenocarcinoma". BMJ. 344 (may16 1): e2476. doi:10.1136/bmj.e2476. PMID 22592847. S2CID 206894869.
  7. ↑ 7.0 7.1 7.2 Wolfgang CL, Herman JM, Laheru DA, Klein AP, Erdek MA, Fishman EK, Hruban RH (September 2013). "Recent progress in pancreatic cancer". CA: A Cancer Journal for Clinicians. 63 (5): 318–48. doi:10.3322/caac.21190. PMC 3769458. PMID 23856911.
  8. ↑ Vincent A, Herman J, Schulick R, Hruban RH, Goggins M (August 2011). "Pancreatic cancer" (PDF). Lancet. 378 (9791): 607–20. doi:10.1016/S0140-6736(10)62307-0. PMC 3062508. PMID 21620466. Archived from the original (PDF) on 12 January 2015.
  9. ↑ "Draft Recommendation Statement: Pancreatic Cancer: Screening – US Preventive Services Task Force". www.uspreventiveservicestaskforce.org. Retrieved 11 February 2019.
  10. ↑ "Can pancreatic cancer be prevented?". American Cancer Society. 11 June 2014. Archived from the original on 13 November 2014. Retrieved 13 November 2014.
  11. ↑ Bardou M, Le Ray I (December 2013). "Treatment of pancreatic cancer: A narrative review of cost-effectiveness studies". Best Practice & Research. Clinical Gastroenterology. 27 (6): 881–92. doi:10.1016/j.bpg.2013.09.006. PMID 24182608.
  12. ↑ Wang H, Naghavi M, Allen C, Barber RM, Bhutta ZA, Carter A, et al. (GBD 2015 Mortality and Causes of Death Collaborators) (October 2016). "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1459–1544. doi:10.1016/s0140-6736(16)31012-1. PMC 5388903. PMID 27733281.
  13. ↑ "Cancer facts and figures – Why we exist – Pancreatic Cancer Research Fund". www.pcrf.org.uk. Retrieved 5 April 2019.
  14. ↑ "Pancreatic Cancer – Cancer Stat Facts". SEER (in Turanci). Retrieved 4 April 2019.
  15. ↑ "Cancer Facts & Figures 2010" (PDF). American Cancer Society. 2010. Archived from the original (PDF) on 14 January 2015. Retrieved 5 December 2014. See p. 4 for incidence estimates, and p. 19 for survival percentages.
  16. ↑ "Pancreatic Cancer Treatment (PDQ®) Health Professional Version". National Cancer Institute. National Institutes of Health. 21 February 2014. Archived from the original on 22 October 2014. Retrieved 24 November 2014. "The highest cure rate occurs if the tumor is truly localized to the pancreas; however, this stage of disease accounts for less than 20% of cases. In cases with localized disease and small cancers (<2 cm) with no lymph-node metastases and no extension beyond the capsule of the pancreas, complete surgical resection is still associated with a low actuarial five-year survival rate of 18% to 24%."

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