Early-onset Alzheimer's disease

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Early-onset Alzheimer's disease (EOAD), also called younger-onset Alzheimer's disease (YOAD),^[1] is Alzheimer's disease diagnosed before the age of 65.^[2] It is an uncommon form of Alzheimer's, accounting for only 5–10% of all Alzheimer's cases. About 60% have a positive family history of Alzheimer's and 13% of them are inherited in an autosomal dominant manner. Most cases of early-onset Alzheimer's share the same traits as the "late-onset" form and are not caused by known genetic mutations. Little is understood about how it starts.

Nonfamilial early-onset AD can develop in people who are in their 30s or 40s, but this is extremely rare,^[3] and mostly people in their 50s or early 60s are affected.