EN2 (gene)

EN2
Identifiers
Aliases	EN2, engrailed homeobox 2
External IDs	OMIM: 131310 MGI: 95390 HomoloGene: 55579 GeneCards: EN2
Gene location (Human)
Chr.	Chromosome 7 (human)
End	155,464,831 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	28,377,164 bp
RNA expression pattern
	Top expressed in
	cerebellar cortex; ; cerebellar hemisphere; ; cerebellar vermis; ; substantia nigra; ; endometrium; ; gastrocnemius muscle; ; caput epididymis; ; Brodmann area 9; ; prefrontal cortex; ; cervix;
	Top expressed in
	cerebellar vermis; ; pineal gland; ; rhombic lip; ; substantia nigra; ; inferior colliculus; ; granular layer; ; interpeduncular nucleus; ; ventral tegmental area; ; pharynx; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	membrane; nucleus; fibrillar center; nucleolus; RSC-type complex;
Biological process	negative regulation of neuron apoptotic process; multicellular organism development; hindbrain development; neuron development; embryonic brain development; regulation of transcription, DNA-templated; midbrain development; positive regulation of transcription by RNA polymerase II; neuron differentiation; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	2020
	13799
	ENSG00000164778
	ENSMUSG00000039095
	P19622
	P09066
	NM_001427
	NM_010134; NM_001395060
	NP_001418
	NP_034264; NP_001381989
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein engrailed-2 is a protein that in humans is encoded by the EN2 gene.^[5] It is a member of the engrailed gene family.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164778 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039095 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EN2 engrailed homeobox 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164778 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039095 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EN2 engrailed homeobox 2".

[1]

[2]

[3]

[4]

[5]