Progesterone receptor

PGR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OAR, 1A28, 1E3K, 1SQN, 1SR7, 1ZUC, 2C7A, 2OVH, 2OVM, 2W8Y, 3D90, 3G8O, 3HQ5, 3KBA, 3ZR7, 3ZRA, 3ZRB, 4A2J, 4APU, 5CC0
Identifiers
Aliases	PGR, NR3C3, PR, progesterone receptor
External IDs	OMIM: 607311 MGI: 97567 HomoloGene: 713 GeneCards: PGR
Gene location (Human)
Chr.	Chromosome 11 (human)
End	101,129,813 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	8,968,612 bp
RNA expression pattern
	Top expressed in
	endometrium; ; germinal epithelium; ; canal of the cervix; ; right uterine tube; ; myometrium; ; seminal vesicula; ; right ventricle; ; caput epididymis; ; lactiferous duct; ; left uterine tube;
	Top expressed in
	substantia nigra; ; uterus; ; ventromedial nucleus; ; facial motor nucleus; ; arcuate nucleus; ; prefrontal cortex; ; lateral hypothalamus; ; mammillary body; ; ventral tegmental area; ; utricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; ATPase binding; zinc ion binding; DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; steroid hormone receptor activity; steroid binding; protein binding; enzyme binding; signaling receptor binding; lipid binding; nuclear receptor activity; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; membrane; nucleoplasm; mitochondrial outer membrane; mitochondrion; nucleus; cytosol;
Biological process	regulation of transcription, DNA-templated; cell-cell signaling; negative regulation of gene expression; transcription, DNA-templated; transcription initiation from RNA polymerase II promoter; signal transduction; steroid hormone mediated signaling pathway; positive regulation of transcription by RNA polymerase II; ovulation from ovarian follicle; epithelial cell maturation; mammary gland development; paracrine signaling; lung alveolus development; regulation of epithelial cell proliferation; progesterone receptor signaling pathway; tertiary branching involved in mammary gland duct morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5241
	18667
	ENSG00000082175
	ENSMUSG00000031870
	P06401
	Q00175
	NM_000926; NM_001202474; NM_001271161; NM_001271162
	NM_008829
	NP_000917; NP_001189403; NP_001258090; NP_001258091
	NP_032855
	Wikidata
View/Edit Human	View/Edit Mouse

The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated by the steroid hormone progesterone.

In humans, PR is encoded by a single PGR gene residing on chromosome 11q22,^[5]^[6]^[7] it has two isoforms, PR-A and PR-B, that differ in their molecular weight.^[8]^[9]^[10] The PR-B is the positive regulator of the effects of progesterone, while PR-A serve to antagonize the effects of PR-B.^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000082175 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031870 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F, Milgrom E (March 1987). "Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA". Biochemical and Biophysical Research Communications. 143 (2): 740–8. doi:10.1016/0006-291X(87)91416-1. PMID 3551956.
^ Law ML, Kao FT, Wei Q, Hartz JA, Greene GL, Zarucki-Schulz T, Conneely OM, Jones C, Puck TT, O'Malley BW (May 1987). "The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2". Proceedings of the National Academy of Sciences of the United States of America. 84 (9): 2877–81. Bibcode:1987PNAS...84.2877L. doi:10.1073/pnas.84.9.2877. PMC 304763. PMID 3472240.
^ ensembl.org, Gene: ESR1 (ENSG00000091831)
^ Gadkar-Sable S, Shah C, Rosario G, Sachdeva G, Puri C (2005). "Progesterone receptors: various forms and functions in reproductive tissues". Frontiers in Bioscience. 10 (1–3): 2118–30. doi:10.2741/1685. PMID 15970482.
^ Kase NG, Speroff L, Glass RL (1999). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-683-30379-7.
^ Fritz MA, Speroff L (2005). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-7817-4795-0.
^ Falcone T, Hurd WW (22 May 2013). Clinical Reproductive Medicine and Surgery: A Practical Guide. Springer Science & Business Media. pp. 39–. ISBN 978-1-4614-6837-0.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000082175 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031870 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3551956-5] Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F, Milgrom E (March 1987). "Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA". Biochemical and Biophysical Research Communications. 143 (2): 740–8. doi:10.1016/0006-291X(87)91416-1. PMID 3551956.

[pmid3472240-6] Law ML, Kao FT, Wei Q, Hartz JA, Greene GL, Zarucki-Schulz T, Conneely OM, Jones C, Puck TT, O'Malley BW (May 1987). "The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2". Proceedings of the National Academy of Sciences of the United States of America. 84 (9): 2877–81. Bibcode:1987PNAS...84.2877L. doi:10.1073/pnas.84.9.2877. PMC 304763. PMID 3472240.

[7] sembl.org, Gene: ESR1 (ENSG00000091831)

[pmid15970482-8] Gadkar-Sable S, Shah C, Rosario G, Sachdeva G, Puri C (2005). "Progesterone receptors: various forms and functions in reproductive tissues". Frontiers in Bioscience. 10 (1–3): 2118–30. doi:10.2741/1685. PMID 15970482.

[isbn0-683-30379-1-9] Kase NG, Speroff L, Glass RL (1999). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-683-30379-7.

[isbn0-7817-4795-3-10] Fritz MA, Speroff L (2005). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-7817-4795-0.

[FalconeHurd2013-11] Falcone T, Hurd WW (22 May 2013). Clinical Reproductive Medicine and Surgery: A Practical Guide. Springer Science & Business Media. pp. 39–. ISBN 978-1-4614-6837-0.

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