Phenylacetone

Phenylacetone
Names
	Preferred IUPAC name 1-Phenylpropan-2-one
	Other names Benzyl methyl ketone; Methyl benzyl ketone; Phenyl-2-propanone
Identifiers
CAS Number	103-79-7 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:52052 ;
ChemSpider	21106366 ;
ECHA InfoCard	100.002.859
KEGG	C15512 ;
PubChem CID	7678;
UNII	O7IZH10V9Y ;
CompTox Dashboard (EPA)	DTXSID1059280 ;
	InChI InChI=1S/C9H10O/c1-8(10)7-9-5-3-2-4-6-9/h2-6H,7H2,1H3 Key: QCCDLTOVEPVEJK-UHFFFAOYSA-N ; InChI=1/C9H10O/c1-8(10)7-9-5-3-2-4-6-9/h2-6H,7H2,1H3 Key: QCCDLTOVEPVEJK-UHFFFAOYAG;
	SMILES O=C(C)Cc1ccccc1;
Properties
Chemical formula	C9H10O
Molar mass	134.178 g·mol−1
Appearance	Colorless, pleasant odor
Density	1.006 g/mL
Melting point	−15 °C (5 °F; 258 K)
Boiling point	214 to 216 °C (417 to 421 °F; 487 to 489 K)
Magnetic susceptibility (χ)	-83.44·10−6 cm3/mol
Legal status	BR: Class D1 (Drug precursors);
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Phenylacetone, also known as phenyl-2-propanone, is an organic compound with the chemical formula C₆H₅CH₂COCH₃. It is a colorless oil that is soluble in organic solvents. It is a mono-substituted benzene derivative, consisting of an acetone attached to a phenyl group. As such, its systematic IUPAC name is 1-phenyl-2-propanone.

This substance is used in the manufacture of methamphetamine and amphetamine, where it is commonly known as P2P.^[2]^[3] Due to illicit drug labs using phenylacetone to make amphetamines, phenylacetone was declared a schedule II controlled substance in the United States in 1980.^[4] In humans, phenylacetone occurs as a metabolite of amphetamine and methamphetamine via FMO3-mediated oxidative deamination.^[5]

^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 15 August 2023.
^ Toske, Steven G.; Brown, Jaclyn L.; Miller, Erin E.; Phillips, Monica Z.; Kerr, Susan C.; Hays, Patrick A. (1 May 2019). "Recent methamphetamine profiling trends: Tracking the nitrostyrene method used for P2P production". Forensic Chemistry. 13: 100140. doi:10.1016/j.forc.2018.12.003. ISSN 2468-1709. S2CID 104413528.
^ "Synthesis of Phenyl-2-Propanone (P2P) - [www.rhodium.ws]". erowid.org. Retrieved 15 April 2023.
^ "Schedules of Controlled Substances; Schedule II Placement of Phenylacetone; (Phenyl-2-propanone, P2P, methyl benzyl ketone, benzyl methyl ketone)" (PDF). Isomer Design. Drug Enforcement Administration. 11 February 1980. Archived (PDF) from the original on 3 March 2022. Retrieved 16 January 2023.
^ Cashman, John R.; Xiong, Yeng N.; Xu, Lifen; Janowsky, Aaron (1 March 1999). "N-Oxygenation of Amphetamine and Methamphetamine by the Human Flavin-Containing Monooxygenase (Form 3): Role in Bioactivation and Detoxication". Journal of Pharmacology and Experimental Therapeutics. 288 (3): 1251–1260. ISSN 0022-3565. PMID 10027866.

[1] Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 15 August 2023.

[2] Toske, Steven G.; Brown, Jaclyn L.; Miller, Erin E.; Phillips, Monica Z.; Kerr, Susan C.; Hays, Patrick A. (1 May 2019). "Recent methamphetamine profiling trends: Tracking the nitrostyrene method used for P2P production". Forensic Chemistry. 13: 100140. doi:10.1016/j.forc.2018.12.003. ISSN 2468-1709. S2CID 104413528.

[3] "Synthesis of Phenyl-2-Propanone (P2P) - [www.rhodium.ws]". erowid.org. Retrieved 15 April 2023.

[4] "Schedules of Controlled Substances; Schedule II Placement of Phenylacetone; (Phenyl-2-propanone, P2P, methyl benzyl ketone, benzyl methyl ketone)" (PDF). Isomer Design. Drug Enforcement Administration. 11 February 1980. Archived (PDF) from the original on 3 March 2022. Retrieved 16 January 2023.

[5] Cashman, John R.; Xiong, Yeng N.; Xu, Lifen; Janowsky, Aaron (1 March 1999). "N-Oxygenation of Amphetamine and Methamphetamine by the Human Flavin-Containing Monooxygenase (Form 3): Role in Bioactivation and Detoxication". Journal of Pharmacology and Experimental Therapeutics. 288 (3): 1251–1260. ISSN 0022-3565. PMID 10027866.

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