List of prime ministers of Elizabeth II

From becoming queen on 6 February 1952, Elizabeth II was head of state of 32 independent states; at the time of her death, there were 15 states, called Commonwealth realms. Within the Westminster system in each realm, the Queen's government was headed by a prime minister. Appointment and dismissal of prime ministers were common reserve powers that could be exercised by Elizabeth or her governors-general.

Elizabeth had 179^N1 individuals serve as her realms' prime ministers throughout her reign, the first new appointment being Dudley Senanayake as Prime Minister of Ceylon and the final being Liz Truss as Prime Minister of the United Kingdom, whom she appointed only two days before her death; some of these individuals served multiple non-consecutive terms in office (within the same state) as prime minister. Several of her prime ministers from various realms were appointed for life to the Privy Council of the United Kingdom.

This list does not cover Commonwealth nations that were not Commonwealth realms at any point during Elizabeth's reign, nor holders of offices of prime minister in colonies or sub-national entities such as states or provinces.