Lopinavir/ritonavir

Lopinavir/ritonavir
Combination of
Lopinavir	Protease inhibitor
Ritonavir	Protease inhibitor (pharmacokinetic booster)
Clinical data
Trade names	Kaletra, Aluvia
AHFS/Drugs.com	Monograph
MedlinePlus	a602015
License data	EU EMA: by INN; US DailyMed: Kaletra;
Pregnancy; category	AU: B3; ;
Routes of; administration	By mouth
ATC code	J05AR10 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only; EU: Rx-only;
Identifiers
CAS Number	369372-47-4 ;
PubChem CID	11979606;
KEGG	D02498;
NIAID ChemDB	003688;
CompTox Dashboard (EPA)	DTXSID30190428 ;
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Lopinavir/ritonavir (LPV/r), sold under the brand name Kaletra among others, is a fixed-dose combination antiretroviral medication for the treatment and prevention of HIV/AIDS.^[2] It combines lopinavir with a low dose of ritonavir.^[2] It is generally recommended for use with other antiretrovirals.^[2] It may be used for prevention after a needlestick injury or other potential exposure.^[2] It is taken by mouth as a tablet, capsule, or solution.^[2]

Common side effects include diarrhea, vomiting, feeling tired, headaches, and muscle pains.^[2] Severe side effects may include pancreatitis, liver problems, and high blood sugar.^[2] It is commonly used in pregnancy and it appears to be safe.^[2] Both medications are HIV protease inhibitors.^[2] Ritonavir functions by slowing down the breakdown of lopinavir.^[2]

Lopinavir/ritonavir as a single medication was approved for use in the United States in 2000.^[2] It is on the World Health Organization's List of Essential Medicines.^[3]

^ "Kaletra Product information". Health Canada. 19 March 2019. Retrieved 18 March 2020.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Lopinavir and Ritonavir". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 28 November 2016.
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.