Lukashenko (Belarusian: Лукашэнка, Ukrainian: Лукашенко) is a Belarusian and Ukrainian surname which means "son of Lukash", the native form of the given name Luke. Notable people with this surname include:
- Alexander Lukashenko (1954), president of Belarus since 1994
- Dmitry Lukashenko (1980), second son of Alexander Lukashenko
- Galina Lukashenko (1955), wife of Alexander Lukashenko
- Nikolay Lukashenko (2004), third son of Alexander Lukashenko
- Viktor Lukashenko (1975), first son of Alexander Lukashenko
- Volodymyr Lukashenko (1980), Ukrainian sabre fencer
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