5-HT1B receptor

HTR1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4IAQ, 4IAR
Identifiers
Aliases	HTR1B, 5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12, 5-HT-1B, 5-HT-1D-beta, 5-hydroxytryptamine receptor 1B
External IDs	OMIM: 182131 MGI: 96274 HomoloGene: 669 GeneCards: HTR1B
Gene location (Human)
Chr.	Chromosome 6 (human)
End	77,463,491 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	81,515,881 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; right coronary artery; ; left coronary artery; ; ascending aorta; ; stromal cell of endometrium; ; prefrontal cortex; ; nucleus accumbens; ; caudate nucleus; ; putamen; ; Brodmann area 9;
	Top expressed in
	ventral nuclear group; ; ventral posteromedial nucleus; ; nucleus accumbens; ; ascending aorta; ; subthalamus; ; ventral posterolateral nucleus; ; olfactory tubercle; ; aortic valve; ; Region I of hippocampus proper; ; pyloric antrum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; G protein-coupled serotonin receptor activity; protein binding; neurotransmitter receptor activity; serotonin binding; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;
Cellular component	cytoplasm; integral component of membrane; membrane; integral component of plasma membrane; plasma membrane; calyx of Held; integral component of presynaptic membrane; serotonergic synapse; dendrite;
Biological process	chemical synaptic transmission; G protein-coupled receptor internalization; regulation of dopamine secretion; regulation of behavior; response to mineralocorticoid; vasoconstriction; adenylate cyclase-inhibiting serotonin receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; cellular response to alkaloid; negative regulation of serotonin secretion; cellular response to temperature stimulus; negative regulation of synaptic transmission, GABAergic; protein kinase C-activating G protein-coupled receptor signaling pathway; drinking behavior; bone remodeling; feeding behavior; response to ethanol; negative regulation of synaptic transmission, glutamatergic; signal transduction; response to cocaine; positive regulation of vascular associated smooth muscle cell proliferation; G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; animal behaviour; presynaptic modulation of chemical synaptic transmission; regulation of synaptic vesicle exocytosis; regulation of presynaptic cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
	3351
	15551
	ENSG00000135312
	ENSMUSG00000049511
	P28222
	P28334
	NM_000863
	NM_010482
	NP_000854
	NP_034612
	Wikidata
View/Edit Human	View/Edit Mouse

5-hydroxytryptamine receptor 1B also known as the 5-HT_1B receptor is a protein that in humans is encoded by the HTR1B gene.^[5]^[6] The 5-HT_1B receptor is a 5-HT receptor subtype.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135312 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049511 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jin H, Oksenberg D, Ashkenazi A, Peroutka SJ, Duncan AM, Rozmahel R, Yang Y, Mengod G, Palacios JM, O'Dowd BF (Mar 1992). "Characterization of the human 5-hydroxytryptamine1B receptor". The Journal of Biological Chemistry. 267 (9): 5735–8. doi:10.1016/S0021-9258(18)42612-9. PMID 1348246.
^ Sanders AR, Cao Q, Taylor J, Levin TE, Badner JA, Cravchik A, Comeron JM, Naruya S, Del Rosario A, Salvi DA, Walczyk KA, Mowry BJ, Levinson DF, Crowe RR, Silverman JM, Gejman PV (Feb 2001). "Genetic diversity of the human serotonin receptor 1B (HTR1B) gene". Genomics. 72 (1): 1–14. doi:10.1006/geno.2000.6411. PMID 11247661.
^ "Entrez Gene: HTR1B 5-hydroxytryptamine (serotonin) receptor 1B".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135312 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049511 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1348246-5] Jin H, Oksenberg D, Ashkenazi A, Peroutka SJ, Duncan AM, Rozmahel R, Yang Y, Mengod G, Palacios JM, O'Dowd BF (Mar 1992). "Characterization of the human 5-hydroxytryptamine1B receptor". The Journal of Biological Chemistry. 267 (9): 5735–8. doi:10.1016/S0021-9258(18)42612-9. PMID 1348246.

[pmid11247661-6] Sanders AR, Cao Q, Taylor J, Levin TE, Badner JA, Cravchik A, Comeron JM, Naruya S, Del Rosario A, Salvi DA, Walczyk KA, Mowry BJ, Levinson DF, Crowe RR, Silverman JM, Gejman PV (Feb 2001). "Genetic diversity of the human serotonin receptor 1B (HTR1B) gene". Genomics. 72 (1): 1–14. doi:10.1006/geno.2000.6411. PMID 11247661.

[entrez-7] "Entrez Gene: HTR1B 5-hydroxytryptamine (serotonin) receptor 1B".

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