Back Cardiolipina Catalan Kardiolipin Czech Cardiolipin Danish Cardiolipine German Cardiolipina Spanish کاردیولیپین Persian Cardiolipine French Cardiolipina Galician Kardiolipin Hungarian Cardiolipina Italian
 General chemical structure of cardiolipins, where R1-R4 are variable fatty acid chains
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| IUPAC name
1,3-bis(sn-3’-phosphatidyl)-sn-glycerol
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3D model (JSmol)
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Cardiolipin (IUPAC name 1,3-bis(sn-3’-phosphatidyl)-sn-glycerol, "sn" designating stereospecific numbering) is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid composition. It can also be found in the membranes of most bacteria. The name "cardiolipin" is derived from the fact that it was first found in animal hearts. It was first isolated from the beef heart in the early 1940s by Mary C. Pangborn.[1] In mammalian cells, but also in plant cells,[2][3] cardiolipin (CL) is found almost exclusively in the inner mitochondrial membrane, where it is essential for the optimal function of numerous enzymes that are involved in mitochondrial energy metabolism.
- ^ Pangborn MC (1942). "Isolation and purification of a serologically active phospholipid from beef heart". Journal of Biological Chemistry. 143: 247–256. doi:10.1016/S0021-9258(18)72683-5.
- ^ Nowicki M, Müller F, Frentzen M (April 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161–2165. Bibcode:2005FEBSL.579.2161N. doi:10.1016/j.febslet.2005.03.007. PMID 15811335. S2CID 21937549.
- ^ Nowicki M (2006). Characterization of the Cardiolipin Synthase from Arabidopsis thaliana (Ph.D. thesis). RWTH-Aachen University. Archived from the original on 2011-10-05. Retrieved 2011-07-11.
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