The Genetical Theory of Natural Selection

The Genetical Theory of Natural Selection

First edition title page
Author	Ronald Fisher
Country	United Kingdom
Language	English
Subject	Evolutionary biology
Publisher	The Clarendon Press
Publication date	1930
OCLC	18500548
Dewey Decimal	575.423
LC Class	QH366 .F5
Preceded by	Statistical Methods for Research Workers
Followed by	The Design of Experiments

The Genetical Theory of Natural Selection is a book by Ronald Fisher which combines Mendelian genetics with Charles Darwin's theory of natural selection,^[1] with Fisher being the first to argue that "Mendelism therefore validates Darwinism"^[2] and stating with regard to mutations that "The vast majority of large mutations are deleterious; small mutations are both far more frequent and more likely to be useful", thus refuting orthogenesis.^[3] First published in 1930 by The Clarendon Press, it is one of the most important books of the modern synthesis,^[4] and helped define population genetics. It is commonly cited in biology books, outlining many concepts that are still considered important such as Fisherian runaway, Fisher's principle, reproductive value, Fisher's fundamental theorem of natural selection, Fisher's geometric model, the sexy son hypothesis, mimicry and the evolution of dominance. It was dictated to his wife in the evenings as he worked at Rothamsted Research in the day.^[5]