NPC1

NPC1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3GKH, 3GKI, 3GKJ, 5F1B, 5F18, 5HNS, 3JD8, 5I31, 5JNX
Dynodwyr
Cyfenwau	NPC1, NPC, NPC intracellular cholesterol transporter 1, SLC65A1, POGZ
Dynodwyr allanol	OMIM: 607623 HomoloGene: 228 GeneCards: NPC1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• virus receptor activity; • lipid transporter activity; • sterol transporter activity; • cholesterol binding; • GO:0001948, GO:0016582 protein binding; • transmembrane signaling receptor activity; • signaling receptor activity;
Cydrannau o'r gell	• integral component of membrane; • fesigl; • endosome; • Golgi apparatus; • nuclear envelope; • bilen; • late endosome membrane; • cellbilen; • integral component of plasma membrane; • extracellular region; • Reticwlwm endoplasmig; • perinuclear region of cytoplasm; • membrane raft; • lysosome; • extracellular exosome; • lysosomal membrane; • integral component of lysosomal membrane;
Prosesau biolegol	• cellular response to steroid hormone stimulus; • steroid metabolic process; • response to cadmium ion; • endocytosis; • negative regulation of macroautophagy; • lipid metabolism; • bile acid metabolic process; • cholesterol transport; • establishment of protein localization to membrane; • cellular response to low-density lipoprotein particle stimulus; • cholesterol metabolic process; • negative regulation of cell death; • autophagy; • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation; • membrane raft organization; • cholesterol efflux; • lysosomal transport; • viral entry into host cell; • cholesterol homeostasis; • GO:0022415 viral process; • adult walking behavior; • GO:0072468 signal transduction; • low-density lipoprotein particle clearance; • intracellular cholesterol transport; • lipid transport;
	Sources:Amigo / QuickGO
Orthologau
	4864
	n/a
	ENSG00000141458
	n/a
	O15118
	n/a
	NM_000271
	n/a
	NP_000262
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NPC1 yw NPC1 a elwir hefyd yn Niemann-Pick C1 protein a NPC intracellular cholesterol transporter 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 18, band 18q11.2.^[2]

[1] "Human PubMed Reference:".

[2] NPC1 - Cronfa NCBI

[1]

[2]