Obesity paradox

The obesity paradox is the finding in some studies of a lower mortality rate for overweight or obese people within certain subpopulations.^[1]^[2]^[3] The paradox has been observed in people with cardiovascular disease and cancer. Explanations for the paradox range from excess weight being protective to the statistical association being caused by methodological flaws such as confounding, detection bias, reverse causality, or selection bias.^[1]

^ ^a ^b Lennon, Hannah; Sperrin, Matthew; Badrick, Ellena; Renehan, Andrew G. (2016). "The Obesity Paradox in Cancer: a Review". Current Oncology Reports. 18 (9): 56. doi:10.1007/s11912-016-0539-4. ISSN 1523-3790. PMC 4967417. PMID 27475805.
^ Flegal, Katherine; Kit, Brian; Orpana, Heather (2 January 2013). "Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories". Journal of the American Medical Association. 309 (1): 71–82. doi:10.1001/jama.2012.113905. PMC 4855514. PMID 23280227.
^ Carnethon, Mercedes; De Chaves, Peter John; Biggs, Mary (8 August 2012). "Association of Weight Status with Mortality in Adults with Incident Diabetes". Journal of the American Medical Association. 308 (6): 581–90. doi:10.1001/jama.2012.9282. PMC 3467944. PMID 22871870.

[Lennon-1] Lennon, Hannah; Sperrin, Matthew; Badrick, Ellena; Renehan, Andrew G. (2016). "The Obesity Paradox in Cancer: a Review". Current Oncology Reports. 18 (9): 56. doi:10.1007/s11912-016-0539-4. ISSN 1523-3790. PMC 4967417. PMID 27475805.

[2] Flegal, Katherine; Kit, Brian; Orpana, Heather (2 January 2013). "Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories". Journal of the American Medical Association. 309 (1): 71–82. doi:10.1001/jama.2012.113905. PMC 4855514. PMID 23280227.

[3] Carnethon, Mercedes; De Chaves, Peter John; Biggs, Mary (8 August 2012). "Association of Weight Status with Mortality in Adults with Incident Diabetes". Journal of the American Medical Association. 308 (6): 581–90. doi:10.1001/jama.2012.9282. PMC 3467944. PMID 22871870.

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