HAMP

HAMP
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1M4E, 1M4F, 2KEF, 3H0T, 4QAE
Identifikatori
Aliasi	HAMP
Vanjski ID-jevi	OMIM: 606464 MGI: 2153530 HomoloGene: 81623 GeneCards: HAMP
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek)[1] Bend 19q13.12 Početak 35,280,716 bp[1] Kraj 35,285,143 bp[1]
Lokacija gena (miš) Hrom. Hromosom 7 (miš)[2] Bend 7 B1|7 19.27 cM Početak 30,621,797 bp[2] Kraj 30,624,106 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • hormone activity • iron ion transmembrane transporter inhibitor activity • signaling receptor binding Ćelijska komponenta • citoplazma • extracellular region • apical cortex • Interkalirani disk • Vanćelijsko Biološki proces • negative regulation of iron export across plasma membrane • negative regulation of intestinal absorption • positive regulation of receptor internalization • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of iron ion transmembrane transporter activity • response to iron ion • multicellular organismal iron ion homeostasis • defense response to bacterium • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • positive regulation of receptor catabolic process • positive regulation of protein polyubiquitination • negative regulation of ion transmembrane transporter activity • cellular iron ion homeostasis • cellular response to lipopolysaccharide • GO:0010260 starenje • cellular response to tumor necrosis factor • liver regeneration • cellular response to bile acid • cellular response to interleukin-6 • response to iron ion starvation • response to vitamin A • response to erythropoietin • positive regulation of cell growth involved in cardiac muscle cell development • response to ethanol • acute-phase response • cellular response to X-ray • response to zinc ion • negative regulation of iron ion transmembrane transport • antimicrobial humoral immune response mediated by antimicrobial peptide • killing of cells of other organism • defense response to fungus • regulation of signaling receptor activity • GO:0072468 Transdukcija signala Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	57817	66438
Ensembl	ENSG00000105697	ENSMUSG00000056978
UniProt	P81172	Q80T19
RefSeq (mRNK)	NM_021175	NM_183257
RefSeq (bjelančevina)	NP_066998	NP_899080
Lokacija (UCSC)	Chr 19: 35.28 – 35.29 Mb	Chr 7: 30.62 – 30.62 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Hepcidin
Struktura rastvora hepcidina-25.[5]
Identifikatori
Simbol	Hepcidin
Pfam	PF06446
InterPro	IPR010500
SCOP2	1m4f / SCOPe / SUPFAM
OPM superporodica	153
OPM protein	1m4e
Dostupne proteinske strukture: Pfam   strukture / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum sažetak strukture

Hepcidin je protein koji je kod ljudi kodiran genom HAMP. Hepcidin je ključni regulator ulaska gvožđa u sisarsku circulaciju.^[6]

Tokom stanja u kojima je nivo hepcidina abnormalno visok, kao što je upala, serumsko gvožđe pada usled zadržavanja u makrofazima i ćelijama jetre i smanjene apsorpcije gvožđa u crijevima. To obično dovodi do anemije zbog neadekvatne količine serumskog gvožđa dostupnog za razvoj crvenih krvnih ćelija. Kada je nivo hepcidina nenormalno nizak, naprimjer kod hemohromatoze, dolazi do preopterećenja gvožđem, zbog povećanog izlivanja gvožđa posredovanog feroportinom iz skladišta i povećane apsorpcije u crijevima.

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000105697 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000056978 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ PDB 1M4F; Hunter HN, Fulton DB, Ganz T, Vogel HJ (oktobar 2002). "The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis". J. Biol. Chem. 277 (40): 37597–603. doi:10.1074/jbc.M205305200. PMID 12138110.
6. ^ Ganz T (august 2003). "Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation". Blood. 102 (3): 783–8. doi:10.1182/blood-2003-03-0672. PMID 12663437.