HAMP

HAMP
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1M4E, 1M4F, 2KEF, 3H0T, 4QAE
Dynodwyr
Cyfenwau	HAMP, HEPC, HFE2B, LEAP1, PLTR, hepcidin antimicrobial peptide
Dynodwyr allanol	OMIM: 606464 HomoloGene: 81623 GeneCards: HAMP
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• hormone activity; • iron ion transmembrane transporter inhibitor activity; • signaling receptor binding;
Cydrannau o'r gell	• cytoplasm; • extracellular region; • apical cortex; • intercalated disc; • extracellular space;
Prosesau biolegol	• negative regulation of iron export across plasma membrane; • negative regulation of intestinal absorption; • positive regulation of receptor internalization; • GO:1901227 negative regulation of transcription by RNA polymerase II; • negative regulation of iron ion transmembrane transporter activity; • response to iron ion; • multicellular organismal iron ion homeostasis; • defense response to bacterium; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • positive regulation of receptor catabolic process; • positive regulation of protein polyubiquitination; • negative regulation of ion transmembrane transporter activity; • cellular iron ion homeostasis; • cellular response to lipopolysaccharide; • GO:0010260 heneiddio; • cellular response to tumor necrosis factor; • liver regeneration; • cellular response to bile acid; • cellular response to interleukin-6; • response to iron ion starvation; • response to vitamin A; • response to erythropoietin; • positive regulation of cell growth involved in cardiac muscle cell development; • response to ethanol; • acute-phase response; • cellular response to X-ray; • response to zinc ion; • negative regulation of iron ion transmembrane transport; • antimicrobial humoral immune response mediated by antimicrobial peptide; • killing of cells of other organism; • defense response to fungus; • regulation of signaling receptor activity; • GO:0072468 signal transduction;
	Sources:Amigo / QuickGO
Orthologau
	57817
	n/a
	ENSG00000105697
	n/a
	P81172
	n/a
	NM_021175
	n/a
	NP_066998
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HAMP yw HAMP a elwir hefyd yn Hepcidin antimicrobial peptide (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.12.^[2]

[1] "Human PubMed Reference:".

[2] HAMP - Cronfa NCBI

[1]

[2]